Ryze

Release a runic blast, dealing 250/430/1500 magic damage. It splits in two, dealing 33% of the damage to the closest two enemies. Each secondary blast splits an additional time.

Bilgewater: Blasts explode on impact, dealing 18% of the damage as physical damage to adjacent enemies.

Demacia: Execute targets below 0.12 Health.

Freljord: Chill targets for 2 seconds and deal X bonus true damage.

Ionia: Blasts split an additional time, dealing 50% damage.

Ixtal: Gain a random Region's effect on combat start and every 10 seconds.

Noxus: Blasts now pierce targets, dealing 60% reduced damage per enemy hit.

Piltover: Every third cast is Overcharged, dealing 40% more damage.

Shadow Isles: Increase blast damage by X.

Shurima: Knock up enemies for 0.5 seconds, with a chance to dredge up Gold or Treasures.

Targon: Heal the lowest Health ally for 10% of the damage dealt.

Void: Ignore 30% of enemies' Armor and Magic Resistance.

Yordle: Shrink targets hit, lowering their damage by 8% percent for 4 seconds.

Zaun: Poison targets, dealing 15/30/500 magic damage X times over 4 seconds.

Exact values aren't in Riot's published Set 16 data (shown as X).